A new STUDY may provide more evidence for why we're seeing successive years of lower #COVID19 infections.
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A new STUDY may provide more evidence for why we're seeing successive years of lower #COVID19 infections.
"PBMCs (peripheral blood mononuclear cells) from individuals who have been infected and vaccinated show enhanced responsiveness, and there are more memory T-cells. Hybrid immunity, resulting from combined infection and vaccination, provides broader and more robust immune responses."
Immunity lasts years. Why is this different from what other studies find? 1/2
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A new STUDY may provide more evidence for why we're seeing successive years of lower #COVID19 infections.
"PBMCs (peripheral blood mononuclear cells) from individuals who have been infected and vaccinated show enhanced responsiveness, and there are more memory T-cells. Hybrid immunity, resulting from combined infection and vaccination, provides broader and more robust immune responses."
Immunity lasts years. Why is this different from what other studies find? 1/2
I have often shared studies that show that immunity fades rapidly. But, we know infections have been declining for years. So, what's up?
I think a big difference in studies is that some merely study antibodies vs. the full immune system, as does this one. Antibody levels do drop after the initial immune response—but studies that measure memory B cells, memory T cells, and long-lived plasma cells typically find much more durable protection. 2/2
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I have often shared studies that show that immunity fades rapidly. But, we know infections have been declining for years. So, what's up?
I think a big difference in studies is that some merely study antibodies vs. the full immune system, as does this one. Antibody levels do drop after the initial immune response—but studies that measure memory B cells, memory T cells, and long-lived plasma cells typically find much more durable protection. 2/2
More details from AI:
Antibody waning ≠ protection waning
A common conceptual error in public communication (less so in research) is conflating falling antibody titers with falling protection. In immunology, the memory B-cell and long-lived plasma cell compartments serve as reservoirs that can rapidly regenerate high-titer antibody responses upon reexposure, even when circulating titers are low. Studies that only report titer decline at fixed intervals miss this reactivation capacity entirely.
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I have often shared studies that show that immunity fades rapidly. But, we know infections have been declining for years. So, what's up?
I think a big difference in studies is that some merely study antibodies vs. the full immune system, as does this one. Antibody levels do drop after the initial immune response—but studies that measure memory B cells, memory T cells, and long-lived plasma cells typically find much more durable protection. 2/2
Yeah, kinda why I get mad when doc tests for antibodies when deciding if I need to get revaccinated for things like Hep B and all that. I don't mind the vaccinations but do wonder how necessary they really are if just based on antibodies being low.
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R relay@relay.mycrowd.ca shared this topic
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More details from AI:
Antibody waning ≠ protection waning
A common conceptual error in public communication (less so in research) is conflating falling antibody titers with falling protection. In immunology, the memory B-cell and long-lived plasma cell compartments serve as reservoirs that can rapidly regenerate high-titer antibody responses upon reexposure, even when circulating titers are low. Studies that only report titer decline at fixed intervals miss this reactivation capacity entirely.
Hmmm. But there have also been a fair number of studies in people where they look at how many vaccinated people get sick compared to how many unvaccinated people get sick, and those studies *also* say that protection wanes, e.g.:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00801-5/fulltext#%20
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R relay@relay.infosec.exchange shared this topic
