@overholt The premise to BLAME!According to the prequel manga NOiSE, the City began as a much smaller structure erected on Earth by the robotic "Builders". Humanity controlled the Builders through the Netsphere, an advanced computer network whose access was restricted to human use only, and authenticated by a genetic marker known as the Net Terminal Gene. Anyone who attempted to access the Netsphere without the marker was eliminated by an automated security force known as the Safeguards. However, a terrorist cult known as "the Order" released a retrovirus that deleted the Net Terminal Gene from all humans, thus cutting off their access to the Netsphere and their control over the Builders. Without specific instructions, the Builders began to build chaotically and indefinitely, while the Safeguards' programming degraded into a mandate to kill all humans without the Net Terminal Gene, whether they wanted to access the Netsphere or not.https://en.wikipedia.org/wiki/Blame!