@cwalkatron okay, this is kind of weird. These started as 16-bit TIFFs in Hasselblad's own colorspace. Whatever. I had their software produce a HEIF, which apparently it silently moved to Rec.2100 PQ rather than their own color profile. Honestly, that's not a bad choice.
Converting the TIFF to AVIC in Photoshop produced a 4.9 MB, 12-bit, 4:4:4 file, still using their own colorspace.
But saving as JPEG XL produced a 2.9 MB file, apparently 16-bit, and in Rec.2100 PQ. Photoshop didn't give me a 4:4:4/4:2:2/4:2:0 or a bit-depth option for JXL.
Both AVIC and JXL were set to "slowest" and Q=90 in Photoshop. JXL saved very quickly, while AVIC seemed substantially slower, although I didn't benchmark either.
I wonder if HEIC and JXL enforce Rec.2100 PQ or something? IMO Rec. 2100 with either PQ or HLG (different transfer functions, basically a fancier replacement for gamma) is probably the best colorspace for web images going forward.