Psychiatry and autoimmunity:
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Psychiatry and autoimmunity:
"And then we did something actually quite novel: We took the [immune] signature of depression and the signature of what dupilumab does in atopic dermatitis patients, and we put the latter on top of the depression signature. We saw that actually, if we extrapolate, dupilumab is likely able to reverse the [immune] phenotype of depression.
That, plus the mouse model experiments, led us to think that probably the type 2 pathway, and maybe inflammation in general, likely play a role in depression. This led to this very novel trial designed by James that, if successful, I think could revolutionize, completely, the way we treat depression."
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Psychiatry and autoimmunity:
"And then we did something actually quite novel: We took the [immune] signature of depression and the signature of what dupilumab does in atopic dermatitis patients, and we put the latter on top of the depression signature. We saw that actually, if we extrapolate, dupilumab is likely able to reverse the [immune] phenotype of depression.
That, plus the mouse model experiments, led us to think that probably the type 2 pathway, and maybe inflammation in general, likely play a role in depression. This led to this very novel trial designed by James that, if successful, I think could revolutionize, completely, the way we treat depression."
"Introduction
Immunological mechanisms may contribute to the causation of mental illness. Autoimmunity is most convincingly shown for anti-NMDA-R encephalitis and Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS); disorders that overlap clinically with schizophrenia and OCD. Altered inflammatory cytokine production, glial activation and auto-antibodies have also been associated with schizophrenia and OCD. In these disorders, however, the treatment results with anti-inflammatory or immunomodulating drugs have hitherto been limited and inconsistent. Yet other targets within the immune system may still be effective and new options are warranted for treatment-resistant patients. Rituximab targets B-lymphocytes and is often used in autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and anti-NMDA-R encephalitis."
"Results
Nineteen patients were treated with rituximab. 3-5 months after treatment, 6/9 patients with schizophrenia and 1/10 with OCD responded. One schizophrenia patient continues with rituximab every 6 months and has reportedly done well for almost 3 years. No severe side effects were reported apart from recurrent abdominal pain in a schizophrenia patient and one case of post-COVID-19 syndrome. Significant changes of FC were detected in responders only and correlated with PSP changes." -
"Introduction
Immunological mechanisms may contribute to the causation of mental illness. Autoimmunity is most convincingly shown for anti-NMDA-R encephalitis and Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS); disorders that overlap clinically with schizophrenia and OCD. Altered inflammatory cytokine production, glial activation and auto-antibodies have also been associated with schizophrenia and OCD. In these disorders, however, the treatment results with anti-inflammatory or immunomodulating drugs have hitherto been limited and inconsistent. Yet other targets within the immune system may still be effective and new options are warranted for treatment-resistant patients. Rituximab targets B-lymphocytes and is often used in autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and anti-NMDA-R encephalitis."
"Results
Nineteen patients were treated with rituximab. 3-5 months after treatment, 6/9 patients with schizophrenia and 1/10 with OCD responded. One schizophrenia patient continues with rituximab every 6 months and has reportedly done well for almost 3 years. No severe side effects were reported apart from recurrent abdominal pain in a schizophrenia patient and one case of post-COVID-19 syndrome. Significant changes of FC were detected in responders only and correlated with PSP changes.""Results: In total, 10 cohort and case control studies were included. From these, 16 control groups were extracted based on nine autoimmune diseases. The meta-analysis demonstrated that the incidence of bipolar disorder was significantly increased in patients with autoimmune disease compared to patients without autoimmune disease, [mean difference (MD) =1.54, 95% confidence interval (CI): 1.28–1.86, P<0.00001]. Also, in the meta-analysis based on five cross-sectional analyses (in which a total of five control groups were extracted based on five autoimmune diseases), the high comorbidity rate of autoimmune diseases and bipolar disorder was verified (MD =2.23, 95% CI: 1.62–3.07, P<0.00001)."
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"Results: In total, 10 cohort and case control studies were included. From these, 16 control groups were extracted based on nine autoimmune diseases. The meta-analysis demonstrated that the incidence of bipolar disorder was significantly increased in patients with autoimmune disease compared to patients without autoimmune disease, [mean difference (MD) =1.54, 95% confidence interval (CI): 1.28–1.86, P<0.00001]. Also, in the meta-analysis based on five cross-sectional analyses (in which a total of five control groups were extracted based on five autoimmune diseases), the high comorbidity rate of autoimmune diseases and bipolar disorder was verified (MD =2.23, 95% CI: 1.62–3.07, P<0.00001)."
I don't think all psychiatric conditions are caused by autoimmunity or infections, obviously, but I think it does cause SOME of them, and that the field of psychiatry generally ignores the evidence in favour of treatment of the symptoms without further investigation.
Shit, like, Prednisone is a general immune suppressant and psychosis is a known side-effect.
We're also seeing increasing evidence of the role of infections and autoimmunity in Alzheimers.
The immune system affects a lot more than your ability to fight a cold.
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I don't think all psychiatric conditions are caused by autoimmunity or infections, obviously, but I think it does cause SOME of them, and that the field of psychiatry generally ignores the evidence in favour of treatment of the symptoms without further investigation.
Shit, like, Prednisone is a general immune suppressant and psychosis is a known side-effect.
We're also seeing increasing evidence of the role of infections and autoimmunity in Alzheimers.
The immune system affects a lot more than your ability to fight a cold.
If I'm completely wrong, I'd love to know how and why. I don't want to spread misinformation, but I also want to know why autoimmunity is so often dismissed as a cause of psychiatric conditions when we know of multiple autoimmune conditions that have profound psychiatric symptoms. Initially, for example, anti-NMDAR encephalitis is basically indistinguishable from well-established psychiatric conditions like bipolar disorder and schizophrenia. Why do we accept those disease are "just" mental illnesses? Are these not neurodegenerative diseases with unknown ultimate causes? Why are we discounting autoimmunity when we don't actually know what the problem is?
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"Introduction
Immunological mechanisms may contribute to the causation of mental illness. Autoimmunity is most convincingly shown for anti-NMDA-R encephalitis and Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS); disorders that overlap clinically with schizophrenia and OCD. Altered inflammatory cytokine production, glial activation and auto-antibodies have also been associated with schizophrenia and OCD. In these disorders, however, the treatment results with anti-inflammatory or immunomodulating drugs have hitherto been limited and inconsistent. Yet other targets within the immune system may still be effective and new options are warranted for treatment-resistant patients. Rituximab targets B-lymphocytes and is often used in autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and anti-NMDA-R encephalitis."
"Results
Nineteen patients were treated with rituximab. 3-5 months after treatment, 6/9 patients with schizophrenia and 1/10 with OCD responded. One schizophrenia patient continues with rituximab every 6 months and has reportedly done well for almost 3 years. No severe side effects were reported apart from recurrent abdominal pain in a schizophrenia patient and one case of post-COVID-19 syndrome. Significant changes of FC were detected in responders only and correlated with PSP changes."Very interesting!! Thank you for sharing this.
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If I'm completely wrong, I'd love to know how and why. I don't want to spread misinformation, but I also want to know why autoimmunity is so often dismissed as a cause of psychiatric conditions when we know of multiple autoimmune conditions that have profound psychiatric symptoms. Initially, for example, anti-NMDAR encephalitis is basically indistinguishable from well-established psychiatric conditions like bipolar disorder and schizophrenia. Why do we accept those disease are "just" mental illnesses? Are these not neurodegenerative diseases with unknown ultimate causes? Why are we discounting autoimmunity when we don't actually know what the problem is?
Well, I think the reason is that we have a history in the west, of considering mental illness to be a moral or spiritual failing, even more than physical disease is
Or maybe physical disease was considered to be just as much that, before the onset of germ theory
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If I'm completely wrong, I'd love to know how and why. I don't want to spread misinformation, but I also want to know why autoimmunity is so often dismissed as a cause of psychiatric conditions when we know of multiple autoimmune conditions that have profound psychiatric symptoms. Initially, for example, anti-NMDAR encephalitis is basically indistinguishable from well-established psychiatric conditions like bipolar disorder and schizophrenia. Why do we accept those disease are "just" mental illnesses? Are these not neurodegenerative diseases with unknown ultimate causes? Why are we discounting autoimmunity when we don't actually know what the problem is?
@PacificNic just to be annoying, I could point out that I've heard anecdotes of people developing autoimmune diseases after suffering some sort of emotional trauma (so, an almost opposite direction of cause/effect). An interconnectedness wouldn't surprise me, in any case
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Psychiatry and autoimmunity:
"And then we did something actually quite novel: We took the [immune] signature of depression and the signature of what dupilumab does in atopic dermatitis patients, and we put the latter on top of the depression signature. We saw that actually, if we extrapolate, dupilumab is likely able to reverse the [immune] phenotype of depression.
That, plus the mouse model experiments, led us to think that probably the type 2 pathway, and maybe inflammation in general, likely play a role in depression. This led to this very novel trial designed by James that, if successful, I think could revolutionize, completely, the way we treat depression."
@PacificNic To be fair, I think if you look at depression as the _mental_ state after trauma etc, this will clearly not help.
We see this only because MDs are shitfucks that call any autoimmune disease and any complex systemic illness like e.g. ME/CFS a "depression" because these idiots refuse to treat patients with respect and dignity.So my theory is: Every single "depression" patient that can be helped by monoclonal autoantibodies has in fact a wrong diagnosis and should have been diagnosed with something else in the first place.
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If I'm completely wrong, I'd love to know how and why. I don't want to spread misinformation, but I also want to know why autoimmunity is so often dismissed as a cause of psychiatric conditions when we know of multiple autoimmune conditions that have profound psychiatric symptoms. Initially, for example, anti-NMDAR encephalitis is basically indistinguishable from well-established psychiatric conditions like bipolar disorder and schizophrenia. Why do we accept those disease are "just" mental illnesses? Are these not neurodegenerative diseases with unknown ultimate causes? Why are we discounting autoimmunity when we don't actually know what the problem is?
@PacificNic I can't speak to this (which is intriguing and I'm going to try to learn more), but inflammation is absolu-frickin'-lutely implicated in some psych disorders. (Not the least of which is that there's good evidence the "fold" survival circuit (which can be triggered by inflammation, and may even have started out that way as a response to make people rest when very sick) is tightly linked to depression.
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R relay@relay.mycrowd.ca shared this topic
